Evaluation and Validation of Radioisotopes Generators-Based Radiotracer for Industrial Applications

Closed for proposals

Project Type

Coordinated Research Project

Project Code

F22044

CRP

1426

Approved Date

6 March 2007

Status

Closed

Start Date

1 July 2007

Expected End Date

30 June 2011

Completed Date

29 September 2011

Description

Radiotracers are widely applied in industries to optimize processes, solve problems, improve product quality, save energy and reduce pollution. However, the radiotracer services are not readily available in many developing countries, mainly because of problems in timely availability of radiotracers as well as their suitability for use in harsh conditions of industrial processes. Producing and using long shelf-life radionuclide generators in a practical solution to the problem. The CRP will identify and coordinate development of industrial radionuclide generators and validate the radionuclide generator-based radiotracers for applications in industrial investigations with emphasis on applicability in field conditions. Guidelines for production of various radiotracers based ort the radionuclide generators will be also developed. The CRP will contribute to larger utilization of industrial radiotracer technology in MS through -the enhanced availability of radionuclide generator- based radiotracers.

Objectives

To investigate the potential of radionuclide generators for industrial radiotracer applications with particular focus on usage in developing MS.

Specific objectives

To develop techniques for the production of various industrial radiotracers from the IRG based radionuclides

To develop portable systems for production of specific radiotracers in connection with the IRGs

To develop techniques for enhancement of long-term stability of the IRGs to extend their shelf-lives

To provide guidelines for the preparation and validation of the IRG based radiotracers

Impact

The generators are of a huge importance and in many cases the only way to have available radiotracers for industrial applications due to the difficulties to obtain radionuclides for radiotracers applications especially in developing MSs. In TC cycle 2012-2013, the technologies and methodologies developed within the CRP will be applied in two regional TC projects (RCA and AFRA) and three national TC projects (in Asia-Pacific, Africa and Latin America regions). Beside these TC projects, technologies and methodologies developed within the CRP will be applied in MSs having participated in the CRP, but also transferred and applied in many MSs not involved in the CRP, for their national activities.

Relevance

The CRP is relevant to the research priorities of the participating countries . They expressed high interest and involvement.

CRP Publications

Type

Publication in Curr Top Med Chem. 10/16 (2010) 1633-68.

Year

2010

Description

The Renaissance of the 68Ge/68Ga radionuclide generator initiates new developments in 68Ga radiopharmaceutical chemistry.

Country/Organization

Germany/ Institute of Nuclear chemistry. Univ. Mainz/ F.Roesch and al.

Type

Publication in Eur J Nucl Med Mol Imaging 37(4) (2010) 834.

Year

2010

Description

PET/CT imaging of osteoblastic bone metastases with 68Ga-bisphosponates - first in human study.

Country/Organization

Germany/ Institute of Nuclear chemistry. Univ. Mainz/ M. Fellner and al.

Type

Publication in Chemistry. 16/24 (2010) 7174-85.

Year

2010

Description

A triazacyclononane-based bifunctional phosphinate ligand for the preparation of multimeric 68Ga tracers for Positron Emission Tomography.

Country/Organization

Germany/ Institute of Nuclear chemistry. Univ. Mainz/ J. Notni and al.

Type

Proceedings of 5th International Conference on Tracers and Tracing Methods», TRACER5, Tiradentes, Brazil

Year

2008

Description

Industrial radiotracer generators

Country/Organization

Institute for Energy Technology (IFE), Kjeller, Norway/ Kristin Fure and al.

Type

Publication in Journal of Chromatography A, 1220,82-91(2012).

Year

2012

Description

Ammonium molybdophosphate impregnated alumina microspheres as a new generation sorbent for chromatographic 137Cs/137mBa generator

Country/Organization

India/ BARC/ A.Dash and al

Type

Publication in Applied Radiation and Isotopes, 70(1):51-58(2012).

Year

2012

Description

Development of a 99Mo/99mTc generator using alumina microspheres for industrial radiotracer applications

Country/Organization

India/ BARC/ A.Dash and al

Type

publication in European Physical Journal (Web of Conferences).

Year

2012

Description

Radiotracer investigations to study the hydrodynamic characteristics of continuous phase in a pulsed sieve plate extraction column,

Country/Organization

Pakistan/ PINSTECH/ G.U.Din and al.

Type

Proceedings of Dalton Transactions 40/23 (2011) 6104-6111

Year

2011

Description

Generator-based PET radiopharmaceuticals for molecular imaging of tumours: On the way to THERANOSTICS

Country/Organization

Germany/ Institute of Nuclear chemistry. Univ. Mainz/ Rösch F and al.

Type

Publication in Nucl Med Biol 35 (2008) 721-724.

Year

2008

Description

Validation of 68Ge/68Ga generator processing by chemical purification for routine clinical application of 68Ga-DOTATOC.

Country/Organization

Germany/ Institute of Nuclear chemistry. Univ. Mainz/ M.Asti and al.

Type

Proceedings of 5th international conference on energy and advancements in process engineering (ICEAPE 2010), Pakistan

Year

2010

Description

Liquid phase axial dispersion study of Taylor bubble flow in a horizontal tube by radiotracer RTD analysis

Country/Organization

Pakistan/PINSTECH/ W.Iqbal and al.

Type

Publication in Separation Science and Technology journal

Year

2012

Description

Development of a 68Ge/68Ga Generator to avail 68Ga in Organic Medium for Industrial Radiotracer Applications

Country/Organization

India/ BARC/ A.Dash and al

Type

Publication in Bioorg Med Chem Let. 18 (2008) 5364–5367.

Year

2008

Description

NODAPA-OH and NODAPA-(NCS)n: Synthesis, 68Ga-radiolabelling and in vitro characterisation of novel versatile bifunctional chelators for molecular imaging.

Country/Organization

Germany/ Institute of Nuclear chemistry. Univ. Mainz/ J.Riss and al.

Type

publication in Radiochimica Acta 98/8 (2010) 519-523.

Year

2010

Description

Studies towards the development of lipophilic bifunctional N3S3 chelators for 68Ga.

Country/Organization

Germany/ Institute of Nuclear chemistry. Univ. Mainz/ P.Riss and al.

Type

Publication in Eur J Nucl Med Mol Imaging. 37(10) (2010) 1935-42.

Year

2010

Description

Activation of P-glycoprotein (Pgp)-mediated drug efflux by extracellular acidosis: in vivo imaging with 68Ga-labelled PET tracer

Country/Organization

Germany/ Institute of Nuclear chemistry. Univ. Mainz/ O.Thews and al.

Type

Publication in J Nucl Med. 48 (2007) 1741-1748.

Year

2007

Description

Processing of generator-produced 68Ga for medical application.

Country/Organization

Germany/ Institute of Nuclear chemistry. Univ. Mainz/ KP. Zhernosekov and al.

Type

Publication in Radiochimica Acta 98/3 (2010) 157-160.

Year

2010

Description

Efficient post-processing of aqueous generator eluates facilitates 68Ga-labelling under anhydrous conditions.

Country/Organization

Germany/ Institute of Nuclear chemistry. Univ. Mainz/ F.Zoller and al.

Type

Applied Radiation Isotopes 69 (2011) 942-6

Year

2011

Description

Improved column-based radiochemical processing of the generator produced 68Ga

Country/Organization

Germany/ Institute of Nuclear chemistry. Univ. Mainz/ Loktionova NS and al.

Type

Publication in Chromatographia, Volume 69, Issue 5 (2009), 497-501

Year

2009

Description

An alumina based 99Mo-99mTc generator to produce 99mTc in organic medium suitable for Industrial Radiotracer Applications

Country/Organization

India/ BARC/ A.Dash and al

Type

Publication in Mol Imaging Biol. 13/5 (2011) 985-994

Year

2011

Description

Thews O. Assessing p-glycoprotein (Pgp) activity in vivo utilizing 68Ga-Schiff base complexes

Country/Organization

Germany/ Institute of Nuclear chemistry. Univ. Mainz/ Fellner M and al.

Type

PhD thesis, Pakistan Institute of Engineering and Applied Sciences,

Year

2009

Description

Radiotracer investigations and modelling of the hydrodynamic characteristics of a liquid-liquid extraction pulsed column

Country/Organization

Pakistan/ PINSTECH/ G.U. Din

Type

Transactions of the Korean Nuclear Society Autumn MeetingGyeongju, Korea, October 27-28, 2011

Year

2011

Description

Feasibility Study on the Radionuclide Generator Based Radiotracer for the Industrial Process Diagnosis Technology

Country/Organization

Korea/ KAERI/ S.H Jung and al.

Type

Publication in Contrast Media Mol Imaging. 6(6) (2011) 492-498.

Year

2011

Description

A convenient multi-gram scale synthesis procedure of functionalized, bivalent, DO2A-based chelators.

Country/Organization

Germany/ Institute of Nuclear chemistry. Univ. Mainz/ Burchardt C and al.

Type

IAEA-TEC-DOC Radioisotopes and radiopharmaceuticals, Series 2: Production of Long Lived Parent Radionuclides for Generators: 68Ge, 82Sr, 90Sr and 188W, ISSN 2077–6462 ; no. 2, STI/PUB/1436, ISBN 978–92–0–101110–7.

Year

2010

Description

Production, radiochemical processing and quality evaluation of Ge-68

Country/Organization

Germany/ Institute of Nuclear chemistry. Univ. Mainz/ F.Roesch and al.

Type

Publication in Nuclear Medicine and Biology 38 (2011) 393–398

Year

2011

Description

Potential use of 68Ga-apo-transferrin as a PET imaging agent for detecting Staphylococcus aureus infection.

Country/Organization

Germany/ Institute of Nuclear chemistry. Univ. Mainz/ V. Kumar and al.

Type

Proceedings of 6th International Conference on Tracers and Tracing Methods», TRACER6, Oslo, Norway

Year

2011

Description

Using isotopes produced from radionuclide generators as tracers for membrane installation investigations

Country/Organization

Poland/ Institute of Radiochemistry and Technology/ A.Miskiewicz and al.

Type

Book : Radionuclide Generators. Handbook of Nuclear Chemistry, Vértes A, Nagy S, Klencsár Z, Lovas RG, Rösch F (eds.) Vol. 4, pp 1935-1976, Second edition, Springer, 2011

Year

2011

Description

Radionuclide Generators. Handbook of Nuclear Chemistry second edition

Country/Organization

Germany/ Institute of Nuclear chemistry. Univ. Mainz/ Rösch F and al.

Type

Publication in Appl. Radiat Isot,

Year

2012

Description

Radiolabeling of DOTATOC with the longer-lived, generator-derived positron emitter 44Sc

Country/Organization

Germany/ Institute of Nuclear chemistry. Univ. Mainz/ M Pruszynski and al.

Type

Norwegian Patent Application No. 20110816,

Year

2011

Description

Radioactively labelled organic tracer, its use and a method for its production

Country/Organization

Institute for Energy Technology (IFE), Kjeller, Norway/ T. Bjornstad and al.

Type

Master of Science Thesis

Year

2010

Description

Development of radiotracer generators for use in industrial processes – the case of 137Cs ? 137mBa

Country/Organization

Institute for Energy Technology (IFE), Kjeller, Norway, and Chalmers University of Technology, Gothenburg, Sweden / Sofie Fredriksson + Tor Bjornstad

Type

Proceedings of 6th International Conference on Tracers and Tracing Methods», TRACER6, Oslo, Norway and publication in EPJ Web of Conferences

Year

2011

Description

Development of an oil tracer labelled with 137mBa

Country/Organization

Institute for Energy Technology (IFE), Kjeller, Norway/ Liv Stavsetra and al.

Type

publication in European Physical Journal (Web of Conferences).

Year

2012

Description

Investigation of liquid phase axial dispersion in Taylor bubble flow by radiotracer residence time distribution analysis,

Country/Organization

Pakistan/ PINSTECH/ R. Chughtai and al.

Type

Publication in Radiochimica Acta 99/1 (2011) 43-51.

Year

2011

Description

Comparison of different phosphorus-containing ligands complexing 68Ga for PET-imaging of bone metabolism

Country/Organization

Germany/ Institute of Nuclear chemistry. Univ. Mainz/ Fellner M and al.

Type

Proceedings of 5th international conference on tracers and tracing methods , Brazil, ISBN N° 978-85-61905-01-09

Year

2008

Description

Axial mixing performance of continuous phase in a pulsed sieve plate extraction column using gallium chloride as radiotracer

Country/Organization

Pakistan/ PINSTECH/ G.U.Din and al.

Type

Publication in Nukleonika, Vol.56, No.1, 2011, p.77-80

Year

2011

Description

Ge-68/Ga-68 radioisotope generator as a source of radiotracers for water flow investigations

Country/Organization

Poland/ Institute of Radiochemistry and Technology/ J.Palige and al.

Type

M.S. Thesis, Pakistan Institute of Engineering and Applied Sciences,

Year

2011

Description

Liquid phase axial dispersion in Taylor bubble flow by residence time distribution analysis in a horizontal tube,

Country/Organization

Pakistan/ PINSTECH/ W. Iqbal

Type

Publication in Bioorg Med Chem Lett 19(13) (2009) 3498-501.

Year

2009

Description

[68Ga]Ga-DO(2)A-(OBu-l-tyr)(2): Synthesis, 68Ga-radiolabeling and in vitro studies of a novel 68Ga-DO(2)A-tyrosine conjugate as potential tumor tracer for PET.

Country/Organization

Germany/ Institute of Nuclear chemistry. Univ. Mainz/ C.BUrchardt and al.

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